Men with the lowest genetic risk of developing prostate cancer could safely avoid invasive investigation, whilst those identified with the greatest risk could be fast-tracked for further investigation. This study is the first to apply GRS in primary care to improve the triage of symptomatic patients. In the lowest quintile, prostate cancer incidence was <1%. Prostate cancer incidence was 8.1% (6.7–9.7) in the highest risk quintile.
An integrated risk model including age and GRS applied to symptomatic men predicted prostate cancer (AUC 0.768 ). ResultsĪ genetic risk score (GRS) is associated with prostate cancer in symptomatic men (OR per SD increase = 2.12 P = 3.5e-30). The predictor was a genetic risk score of 269 genetic variants for prostate cancer. The outcome measure was prostate cancer diagnosis within 2 years of consultation. Participants were men with a record showing a general practice consultation for a lower urinary tract symptom. MethodsĬohort study using UK Biobank data linked to primary care records. It commonly presents with non-specific lower urinary tract symptoms that are frequently associated with benign conditions. Prostate cancer is highly heritable, with >250 common variants associated in genome-wide association studies.
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